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The Cheyenne were heavily involved in conflicts with the US government around 1864, particularly during the events leading up to and including the Sand Creek Massacre. This tragic event, which occurred in November 1864, involved the killing of hundreds of Cheyenne and Arapaho people by Colorado U.S. Volunteer Cavalry, under the command of Colonel John Chivington. The incident highlighted the violent tensions existing between Native American tribes and the US government as settlers expanded westward, exacerbating territorial disputes and escalating hostilities.
The Cheyenne's resistance was part of broader conflicts involving various tribes seeking to defend their lands and way of life against encroachment by settlers and military forces. This period was marked by numerous treaties and conflicts, as different Native American tribes, including the Cheyenne, attempted to navigate the pressures of westward expansion and federal policies that often disregarded their rights and territorial claims.